| Autor: | Paul C. Billings, Harry Rozmiarek, Catherine J. Harvey, Ann Kennedy, Eva L. Emmel, James V. Hawkins, Mark A. Nedelman, Jennifer J. Feuer, Gary R. Lichtenstein, Hilton J. Klein |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal tract Proteases Protease medicine.diagnostic_test Physiology business.industry medicine.medical_treatment Gastroenterology Biological activity medicine.disease Inflammatory bowel disease Ulcerative colitis digestive system diseases Biopsy Immunology medicine Histopathology business |
| Zdroj: | Digestive Diseases and Sciences. 42:1969-1980 |
| ISSN: | 0163-2116 |
| DOI: | 10.1023/a:1018887832465 |
| Popis: | Inflammatory bowel disease (IBD) is a painful and debilitating condition affecting the mucosal lining of the colon and other areas of the gastrointestinal tract. IBD generally falls into two major categories: ulcerative colitis (UC) and Crohn's disease. We have utilized dinitrobenzenesulfonic acid (DNBS) to induce experimental UC in rats. Histopathologic analysis indicates that DNBS induces a condition in animals similar to human UC. Biochemical results revealed 6- to 10-fold elevated levels of serine protease activity in colon tissue from animals with UC as compared with matched controls. We also observed elevated levels of protease activity in tissue samples obtained from human patients with UC. Hence, our results demonstrate that protease activity is increased in rodent and human UC. These proteases may play a significant role in destruction of colonic tissue in IBD. Protease inhibitors that target serine proteases may be useful pharmacological agents to limit tissue destruction in IBD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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