Synthesis and structure ofN1-e-benzo-4,7,13,16,21,26-hexaoxa-1,10-diazabicyclo[8.8.8]hexacos-23-yl-N2-phenylthiourea. Derivative of a bifunctional complexing agent

Autor:	William A. Pettit, Yoshihisa Iwai, Charles F. Barfknecht, Dale C. Swenson
Rok vydání:	1992
Předmět:	chemistry.chemical_compound Aniline chemistry Thiourea Organic Chemistry Cryptand Free base Amine gas treating Crystal structure Bifunctional Medicinal chemistry Derivative (chemistry)
Zdroj:	Journal of Heterocyclic Chemistry. 29:877-881
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570290434
Popis:	A cryptand with an aminobenzo group 4,7,13,16,21,24-hexaoxa-5,6-(4′-aminobenzo)-1,10-diazabicyclo-[8.8.8]hexacosane, has been synthesized as a bifunctional complexing intermediate for investigation of the labeling of proteins with metal radionuclides. This amine, although unstable, can be prepared as the stable stannic salt. The free base was converted to the corresponding phenylthiourea by 1) reaction with phenyliso-thiocyanate and 2) conversion to its isothiocyanate followed by reaction with aniline. The thiourea structure was confirmed by X-ray crystallographic analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15a42832bc6e0cdebb259f614089b4a6 https://doi.org/10.1002/jhet.5570290434 Zobrazit plný text záznamu Plný text