| Autor: | Nicolas Spassky, Marie‐Odile Sepulchre, J.-P. Guette, Michel Reix |
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| Rok vydání: | 1983 |
| Předmět: | |
| Zdroj: | Die Makromolekulare Chemie. 184:17-28 |
| ISSN: | 0025-116X |
| DOI: | 10.1002/macp.1983.021840103 |
| Popis: | The kinetics of hydrolysis of D- and L-histidine methyl ester were studied in the presence of crosslinked hydrophilic polymeric supports bearing L-histidine moieties complexed with Ni2+ salt. The selectivity of hydrolysis (kD/kL ratio) rises with the increase of the hydrophilic character (content of monomeric units of 2-hydroxyethyl methacrylate) of the resin. It varies with the ratio ester / catalytic moiety, the best result being obtained when the latter is close to 1. The selectivity depends on the temperature and an inversion of this selectivity is observed at 31°C. The optimization of all the parameters studied allowed to reach the same enantioselectivity and comparable rates of hydrolysis as observed in a model reaction carried out under homogeneous conditions. |
| Databáze: | OpenAIRE |
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