A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates

Autor: Tingxizi Liang, Xiaoman Duan, Keli An, Qi Shen, Xigao Chen, Chen Wang, Penghui Zhang, Xiaoshu Pan, Yifan Lyv, Feng Xu, Jie Liu, Yu-Chao Zhang, Weihong Tan, Cheng Cui, Di Gao, Jun-Jie Zhu, Xiaoxiao Hu, Tielin Yang
Rok vydání: 2020
Předmět:
Zdroj: Nature Chemistry. 12:381-390
ISSN: 1755-4349
1755-4330
Popis: Stimuli-responsive biomaterials that contain logic gates hold great potential for detecting and responding to pathological markers as part of clinical therapies. However, a major barrier is the lack of a generalized system that can be used to easily assemble different ligand-responsive units to form programmable nanodevices for advanced biocomputation. Here we develop a programmable polymer library by including responsive units in building blocks with similar structure and reactivity. Using these polymers, we have developed a series of smart nanocarriers with hierarchical structures containing logic gates linked to self-immolative motifs. Designed with disease biomarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (including kinase inhibitors, drugs and short interfering RNA) in vitro and in vivo. We expect that this 'plug and play' platform will be expanded towards smart biomaterial engineering for therapeutic delivery, precision medicine, tissue engineering and stem cell therapy.
Databáze: OpenAIRE
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