Liposomal doxorubicin-loaded chitosan microspheres capable of controlling release of doxorubicin for anti-cancer chemoembolization: in vitro characteristics

Autor:	Jaehwi Lee, Byung Kook Kwak, Hyeongmin Kim, Ga-Hyeon Lee, Hyo-Jeong Kuh
Rok vydání:	2013
Předmět:	Drug Liposome Chromatography Liposomal Doxorubicin media_common.quotation_subject Pharmaceutical Science Pharmacology In vitro Chitosan chemistry.chemical_compound chemistry Drug release medicine Doxorubicin media_common Chitosan microspheres medicine.drug
Zdroj:	Journal of Drug Delivery Science and Technology. 23:283-286
ISSN:	1773-2247
DOI:	10.1016/s1773-2247(13)50042-6
Popis:	The aim of this study was to develop liposomal doxorubicin-loaded chitosan microspheres (LDox-CSMS) for anti-cancer chemoembolization. LDox-CSMS and doxorubicin-loaded CSMS (Dox-CSMS) devoid of liposomal carrier were prepared with an emulsification and cross-linking method. Various stirring rates were required to obtain large fractions of CSMS in the size range of 300–500 μm. Drug loading amounts were considerably influenced by the amount of doxorubicin-loaded liposomes added. Drug release from LDox-CSMS was controlled by the drug loading amount, which was varied by the addition of liposomal doxorubicin. These results indicate that LDox-CSMS can be used as an advanced chemoembolic agent that can control drug release behaviors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15888b4f97a0e215cce828fcf5e95d0f https://doi.org/10.1016/s1773-2247(13)50042-6 Zobrazit plný text záznamu Full Text from ScienceDirect