Ultrasound assessment of diaphragmatic function in patients with amyotrophic lateral sclerosis
| Autor: | Andrea Iattoni, Roberto Tonelli, Alessandro Marchioni, Riccardo Fantini, Enrico Clini, Federico Antenora, Marco Monelli, Jessica Mandrioli, Nicola Fini, Stefano Zona |
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| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Vital capacity medicine.diagnostic_test business.industry Diaphragmatic breathing Pulmonary function testing Diaphragm (structural system) 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine 030228 respiratory system Anesthesia medicine Lung volumes business 030217 neurology & neurosurgery Tidal volume |
| Zdroj: | Respirology. 21:932-938 |
| ISSN: | 1323-7799 |
| DOI: | 10.1111/resp.12759 |
| Popis: | Background and objective Evaluation of diaphragm function in Amyotrophic Lateral Sclerosis (ALS) is critical in determining when to commence non-invasive mechanical ventilation (NIV). Currently, forced vital capacity (FVC) and sniff nasal inspiratory pressure (SNIP) are volitional measures for this evaluation, but require collaboration and are poorly specific. The primary aim of this study was to assess whether diaphragmatic thickness measured by ultrasound (US) correlates with lung function impairment in ALS patients. The secondary aim was then to compare US diaphragm thickness index (ΔTdi) with a new parameter (ΔTmax index). Methods 41 patients with ALS and 30 healthy subjects were enrolled in the study. All subjects underwent spirometry, SNIP and diaphragm US evaluation, while arterial blood gases were measured in some patients only. US assessed diaphragm thickness (Tdi) at tidal volume (Vt) or total lung capacity (TLC), and their ratio (ΔTmax) were recorded. Changes (Δ) in Tdi indices during tidal volume (ΔTdiVt) and maximal inspiration (ΔTdiTLC) were also assessed. Results ΔTdiTLC (p |
| Databáze: | OpenAIRE |
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