Epicutaneous aeroallergen sensitization in atopic dermatitis infants - determining the role of epidermal barrier impairment
| Autor: | M. Fayon, Alain Taieb, Christine Léauté-Labrèze, S. Maurice-Tison, S. Roul, Franck Boralevi, T. Hubiche, E. Saubusse |
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| Rok vydání: | 2008 |
| Předmět: |
House dust mite
Allergy medicine.medical_specialty Transepidermal water loss biology business.industry Immunology Aeroallergen Atopic dermatitis medicine.disease_cause medicine.disease biology.organism_classification Dermatology Atopy medicine.anatomical_structure Allergen medicine Immunology and Allergy business Sensitization |
| Zdroj: | Allergy. 63:205-210 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/j.1398-9995.2007.01556.x |
| Popis: | Background: Sensitization to atopens is an early phenomenon that overlaps with the onset of atopic dermatitis (AD) in infancy. Early epidermal barrier impairment may facilitate the epicutaneous penetration of atopens. Objective: To correlate transepidermal water loss (TEWL) and aeroallergen sensitization in infants with AD. Methods: In this cross-sectional study we enrolled 59 AD children and 30 controls aged 3–12 months. Transepidermal water loss in uninvolved skin, specific immunoglobulin E, atopy patch test (APT) and skin prick tests were performed with respect to seven aeroallergens, i.e., Dermatophagoides pteronyssinus, D. farinae, cat, dog, birch pollen, ambrosia, and cockroach. Environmental conditions were assessed by a questionnaire, and the house dust mite (HDM) concentration was determined in dust samples. Results: Eighty-nine percent of AD infants had a positive APT vs one out of eleven controls. AD infants had a significantly higher mean TEWL than controls (27.4 vs 11.1 g/m2/h, P |
| Databáze: | OpenAIRE |
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