Predictive value of response to treatment of T-lymphocyte subpopulations in idiopathic pulmonary fibrosis
| Autor: | E Fireman, N Vardinon, M Burke, S Spizer, S Levin, A Endler, D Stav, M Topilsky, A Mann, Y Schwarz, S Kivity, J Greif |
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| Rok vydání: | 1998 |
| Předmět: | |
| Zdroj: | European Respiratory Journal. 11:706-711 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.98.11030706 |
| Popis: | T-cell types are important in maintaining immune homeostasis in the lung and their imbalance may be associated with several diseases. We examined the relationship between bronchoalveolar lavage (BAL) T-cell subset profiles and the clinical course of 46 patients with idiopathic pulmonary fibrosis (IPF). A flow cytometry cell sorter (FACS) was used to analyse the T-cell subsets. Pulmonary function tests (PFT) were performed at baseline and 6-12 months later. Patients were divided into two groups according to their CD4/CD8 ratio: CD4/CD8 >1 (group 1, n=21); and CD4/CD8 1 and a low percentage of CD8/S6F1 may have a more benign course of disease. These parameters may identify an early stage of reversible disease responsive to therapy. We conclude that these measurements may be a useful tool in monitoring response to treatment in patients with idiopathic pulmonary fibrosis. |
| Databáze: | OpenAIRE |
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