Polysomies but not Y chromosome losses have prognostic significance in pTa/pT1 urinary bladder cancer*1
| Autor: | Michael J. Mihatsch, Urs Wagner, Guido Sauter, Holger Moch, Marcus Rist, Thomas Gasser, Ulrico Schmid, Daniel Ackermann, Robert Maurer, Tobias Zellweger, Göran Alund, Michael Neuhaus, Hartmut Knönagel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Urinary bladder medicine.diagnostic_test Cell Biology Y chromosome medicine.disease Pathology and Forensic Medicine Chromosome 17 (human) medicine.anatomical_structure Transitional cell carcinoma Bladder Neoplasm medicine Fluorescence in situ hybridization Comparative genomic hybridization |
| Zdroj: | Human Pathology. 30:81-86 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/s0046-8177(99)90305-2 |
| Popis: | A disturbed cellular DNA content is of potential diagnostic and prognostic relevance in urinary bladder cancer. To evaluate the prognostic significance of individual chromosomal aberrations in superficial bladder cancer, specimens of 105 tumors (67 pTa, 38 pTl) were examined by fluorescence in situ hybridization (FISH). FISH allows quantitation of chromosomes on a cell by cell level. Centromere probes for the chromosomes Y, 1, and 17 were used. There was a strong association between polysomies of the chromosomes 1 (found in 46% of tumors) and 17 (40% of tumors, P P P |
| Databáze: | OpenAIRE |
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