EVALUATION OF ANTI-SEIZURE ACTIVITY OF SIDA RHOMBIFOLIAALONE AND IN COMBINATION WITH ANTI-SEIZURE DRUGS IN SWISS ALBINO MICE
| Autor: | Ruchika Kalra, Bhargav M. Purohit, Ashish P Anovadiya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Sida rhombifolia
biology Traditional medicine business.industry biology.organism_classification 01 natural sciences 030205 complementary & alternative medicine 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences 0302 clinical medicine Medicine Seizure activity business |
| Zdroj: | INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. :1-3 |
| DOI: | 10.36106/ijsr/6731449 |
| Popis: | Background-Anti-seizure activity of Sida Rhombifolia in low (300mg/kg) and high doses(600mg/kg) and its combination with Phenytoin(50mg/kg) and Sodium valproate(300mg/kg) were studied in chronic model (14 days) of Maximal Electroshock Seizure (MES) and Pentylenetetrazole (PTZ) induced seizure respectively. Methods- Anti-seizure activity of Sida Rhombifolia on generalized tonic-clonic seizure and absence seizure was evaluated using standard maximal electroshock seizure method and pentylenetetrazole test. Results- In MES induced seizures Sida Rhombifolia in high dose prevented both tonic extension and tonic flexion. In PTZ induced seizures Sida Rhombifolia in high dose significantly (p0.05). The addition of Sida Rhombifolia to the sub- therapeutic dose of sodium valproate and phenytoin showed a synergistic effect. Conclusion- Inhibition of seizure by Sida Rhombifolia could be due to the presence of flavonoids that acts as a partial positive allosteric modulator at GABAA (γ-aminobutyric acid) receptors, penetrates the blood-brain barrier and possess the anti-convulsant activity and also because of its antioxidant property. Sida Rhombifolia can be effective in generalized tonic-clonic seizures alone and as add on with sodium valproate for absence seizures. |
| Databáze: | OpenAIRE |
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