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Two different fractions were prepared from whole colostrum: defatted colostrum (DC) and low molecular weight components of colostrum (LMC), and their effect on the growth dynamics of Wistar rats, in which liver fibrosis was induced, and the content of erythrocytes, platelets, and immunocompetent cells (leukocytes, lympho-cytes, granulocytes, monocytes). To induce liver fibrosis, rats were injected three times with copper sulfate at a dose of 1 mg /100 g of body weight with an interval of 48 hours between injections. 24 hours after the last admin-istration of copper, the development of the initial stage of fibrosis was observed according to histology data, and this was accompanied by an inhibition of the rate of growth in the body weight of the animals. Hematological parameters were determined on an automatic analyzer Mindray BC 2008 Vet, (USA). It was found that in animals with fibrosis the number of platelets was increased by 2 times in comparison with the control, other types of cells, in particular immunocompetent cells, remained within the normal range. If animals with Cu-induced fibrosis were injected with OM and NCM at a dose of 0.1 mg /100 g of body weight daily for 6 days, then there was a significant increase in the number of immunocompetent cells in the bloodstream (leukocytes by 80% with OM and 59 % for NCM; lymphocytes by 68% and 30%, respectively; monocytes by 82% for OM and 160% for NCM; granulocytes by 218% and 223%, respectively), with a decrease in the number of platelets compared to animals with fibrosis. It has been suggested that the components of colostrum have a stimulating effect on the functional activity of bone marrow cells, which can contribute to the elimination of liver fibrosis. DC and LMC had different effects on the content of different types of bone marrow cells. |
