ChemInform Abstract: Synthesis of Certain 5-Substituted Thieno[2,3-b]thiophene-2-sulfonamides and Thieno[2,3-b]thiophene-2-sulfonamide 6,6-Dioxides

Autor:	Vincent M. Lynch, Hwang Hsing Chen, Jesse A. May
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Chemistry Carbonic anhydrase II Thiophene Organic chemistry General Medicine Thiophene derivatives Sulfonamide
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199931135
Popis:	A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides provided the first examples of thiophene[2,3-b]thiophene-2-sulfonarnide 6,6-dioxides. These cyclic vinyl sulfones readily underwent addi tion to give predominately that 4,5-cis addition product.
Databáze:	OpenAIRE
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