Hepatoprotective Activity of Tectona grandis Against CCl4-Induced Hepatic Damage in Rats
| Autor: | Jaspreet Sidana, Geeta Deswal, Priyanka Kriplani, Kumar Guarve, Bhawna Chopra, Ashwani Kumar Dhingra |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology Chemistry Pharmaceutical Science CCL4 biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences 0302 clinical medicine Hepatic damage Tectona 030220 oncology & carcinogenesis Drug Discovery medicine Molecular Medicine Histopathology |
| Zdroj: | The Open Pharmacology Journal. 9:5-11 |
| ISSN: | 1874-1436 |
| Popis: | Background:Literature reports numerous causes for liver damage, which mainly include viral hepatitis (most commonly hepatitis B), cirrhosis, cell stress, hepatic damage by NSAIDs or alcohol. In the present study, methanolic extracts ofTectona grandisleaves were evaluated for hepatoprotective activity against CCl4induced liver damage in rats.Methods:Hepatic injury in rats was carried out using the CCl4-induced hepatotoxic model. Methanolic extracts ofTectona grandiswere administered orally at two different doses (200mg/kg & 400mg/kg) daily. The biochemical parameters (SGOT, SGPT, ALP, and serum bilirubin) were estimated using Reitman and Frankel's method in addition Kind King’s method.Results:The preliminary phytochemical studies confirmed the existence of saponins, carbohydrates, tannins, and flavonoids. CCl4treated group boost the concentrations of Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphate (ALP) and serum bilirubin as compared to control group (rats treated with vehicle). The methanolic extract of plant (200 mg/kg & 400 mg/kg) and standard drug silymarin (100 mg/kg) produced a significant decrease in raised levels of these enzymes as compared to control.Conclusion:The results clearly indicate thatTectona grandisleaves have notable hepatoprotective activity in rats hepatic damage induced by CCl4. |
| Databáze: | OpenAIRE |
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