Antihyperglycemic Activity of Murraya koenigii Leaves Extract on Blood Sugar Level in Streptozotocin-Nicotinamide Induced Diabetes in Rats
| Autor: | Somnath M. Matule, Rohan Sharadanand Phatak, Chitra C. Khanwelkar, Kailas D. Datkhile, Anup Subhash Hendre |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
0303 health sciences Murraya biology Blood sugar Streptozotocin nicotinamide biology.organism_classification medicine.disease Metformin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Alloxan Diabetes mellitus medicine 030304 developmental biology Experimental diabetes medicine.drug |
| Zdroj: | Biomedical and Pharmacology Journal. 12:597-602 |
| ISSN: | 2456-2610 0974-6242 |
| Popis: | The effects of Murraya koenigii leaves are very less studied in streptozotocin-nicotinamide (STZ-NA) induced diabetes rat model, in spite of several studies reported its antidiabetic effects in alloxan and STZ induced diabetes. The present study was undertaken to assess the effects of Murraya koenigii leaves extract on the blood sugar level (BSL) of STZ-NA diabetic rats. Experimental diabetes was induced by STZ injection intraperitoneally (i. p) after 30 min of NA injection i. p in all groups apart from normal control group. Group I (normal control) and Group II (diabetic control) rats received distilled water. Group III rats treated Metformin, Group IV and Group V rats treated Murraya koenigii aqueous extract and Murraya koenigii methanolic extract respectively. BSL and body weights of rats were measured at each week of the period of 28 days. Our results indicate that oral administration of Murraya koenigii reduces BSL significantly compared with the diabetic group. No weight loss was observed in all groups. The findings of the present study suggest that Murraya koenigii is proven as anti-diabetic agent in diabetic rats. |
| Databáze: | OpenAIRE |
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