Effects of oral probiotic supplementation on gut Lactobacillus and Bifidobacterium populations and the clinical status of low-birth-weight preterm neonates: a multicenter randomized, double-blind, placebo-controlled trial
| Autor: | Ryszard Lauterbach, Magdalena Strus, Katarzyna Nowicka, Maria Wilińska, Małgorzata Rudnicka, Piotr B Heczko, Aleksandra Mikołajczyk-Cichońska, Beata Rzepecka-Węglarz, Aneta Waśko, Ewa Helwich, Marek Szczepański, Jerzy Szczapa, Anna Tomusiak-Plebanek, Helena Sławska |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
ved/biology.organism_classification_rank.species Gut flora Gastroenterology law.invention Sepsis 03 medical and health sciences Probiotic 0302 clinical medicine Lactobacillus rhamnosus law 030225 pediatrics Internal medicine Lactobacillus medicine Pharmacology (medical) 030212 general & internal medicine Bifidobacterium Pharmacology Bifidobacterium breve biology business.industry ved/biology biology.organism_classification medicine.disease Infectious Diseases Gastrointestinal function business |
| Zdroj: | Infection and Drug Resistance. 11:1557-1571 |
| ISSN: | 1178-6973 |
| DOI: | 10.2147/idr.s166348 |
| Popis: | Aim Probiotic bacteria administered directly after birth to preterm neonates may improve gastrointestinal function and may reduce the incidence of late-onset sepsis, which is a frequent complication in this group. Purpose The main objective of this study was to evaluate whether a new probiotic bacterial mixture of Lactobacillus rhamnosus KL53A and Bifidobacterium breve PB04 given to preterm, low-birth-weight neonates would influence composition of their gut microbiota and sepsis rates. Patients and methods This study was a multicenter, randomized, double-blind, placebo-controlled trial conducted in clinical centers of neonatal care in Poland. A probiotic or placebo preparation was given twice daily to 181 preterm low-birth-weight neonates who were eligible for enteral feeding between July 2012 and July 2013. The probiotic was given to 90 neonates, while placebo was given to 91 neonates. The gut microbiota was monitored by microbiological analysis of stool samples. Sepsis episodes were detected on the basis of clinical and laboratory findings and confirmed by blood cultures. Results Tested probiotic administration resulted in continuous increase of the Lactobacillus and Bifidobacterium counts in the gut microbiota. The applied tested strains successfully colonized the neonates gut since they were present in over 90% of stool samples, which was confirmed by molecular analysis. Regardless of the study group (probiotic or placebo), B. breve colonization correlated with lower staphylococcal sepsis incidence, which was irrespective of whether probiotics were given. No sepsis case caused by strains included in study probiotic was recorded. Conclusion Appropriately selected and characterized probiotic bacteria may be safely given to preterm neonates to normalize their distorted gut microbiota and may contribute to lower staphylococcal sepsis rates. |
| Databáze: | OpenAIRE |
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