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Objectives：The purpose of this study was to investigate the reproductive effect of Ginseng radix on male mice.Methods：Male C57BL/6J mice were divided into four groups； normal group (vehicle-treated, n=8), Ginseng radix treatment group (100, 500, 1000 mg/kg, n=8). Ginseng radix extract was treated for 5 weeks. After treatment each group was examined for assessment of sperm count and CatSper protein expression using computer assisted semen analysis (CASA) system and the immunofl uorescence.Results：Sperm count of normal and Ginseng radix extract treated group w ere 287.57 vs. 371.62, 364.83, 343.29 x10 6 , respectively. The CatSper3, 4 proteins expression of Ginseng radix treated group were significantly increased than that of normal group.Conclusions：These findings suggest that the Ginseng radix improves male rep roductive function by increasing sperm count and CatSper protein expression.Key words：Ginseng radix, Sperm count, Cation channel of Sperm (CatSper) 서 론 불임이란 피임을 하지 않고 1년 이상 정상적인 부부생활을 하면서 임신하지 못하는 것으로, 불임부부는 전체 부부의 10-20%를 차지하고 있다. 불임의 원인은 여성에게만 있는 경우가 약 40%, 남성에게만 있는 경우가 약 40%, 남성과 여성 양쪽 모두에게 있는 경우가 약 10%, 원인불명인 경우가 약 10%로 나타내며, 결과적으로 그 원인의 절반은 남성요인이라 할 수 있다 |
