Synthesis and bioactivity of a novel bismuthoxide Schiff-base complex derived from Salen-like ligand and bismuth(III) nitrate
| Autor: | Jin-Qi Xie, Hui-Wen Gu, Chao Jiang, De-Liang Wei, Meng-Na Peng, Qiang-Guo Li, Chuan-Hua Li, Xu Li, Jian-Hong Jiang, Sheng-Xiong Xiao |
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| Rok vydání: | 2016 |
| Předmět: |
Isothermal microcalorimetry
Schiff base biology 010405 organic chemistry Stereochemistry Ligand Bismuth(III) nitrate Infrared spectroscopy General Chemistry 010402 general chemistry biology.organism_classification 01 natural sciences Medicinal chemistry 0104 chemical sciences NMR spectra database chemistry.chemical_compound Reaction rate constant chemistry Schizosaccharomyces pombe |
| Zdroj: | Chemical Research in Chinese Universities. 32:207-211 |
| ISSN: | 2210-3171 1005-9040 |
| DOI: | 10.1007/s40242-016-5350-0 |
| Popis: | In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8(vanen)3(NO3)2(CH3OH)2(H2O)·3NO3·5.5H2O](abbreviated as Bivanen) was synthesized with Salen-like ligand[H2vanen=N,N’-ethylene bis(3-methoxy-salicylideneimine)] and bismuth(III) nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaccharomyces pombe (S. pombe) were studied using biological microcalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 °C. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant(k), inhibition ratio(I) and half inhibition concentration(IC50) were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively. |
| Databáze: | OpenAIRE |
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