Reaction Engineering of Biocatalytic Enantioselective Reduction: A Case Study for Aliphatic Ketones

Autor:	Susanne Leuchs, John M. Woodley, Joana Lima-Ramos, Naweed Al-Haque, Lasse Greiner, Pär Tufvesson
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Green chemistry Ketone Chemical reaction engineering Nicotinamide Organic Chemistry Enantioselective synthesis Raw material chemistry.chemical_compound chemistry Scientific method Ionic liquid Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 17:1027-1035
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op400117t
Popis:	Previously, it could be demonstrated, that the monophasic, enzymatic reduction of aliphatic 2-ketones into the corresponding (R)-2-alcohols is an adequate and viable method as carried out in a cascade of two enzyme–membrane reactors (Leuchs, S.; Na’amnieh, S. N.; Greiner, L. Green Chemistry 2013, 15, 167–176.). In the present work, the process metrics of the ketone reduction were calculated. A cost analysis revealed that the enzyme costs are negligible, but the cost for nicotinamide cofactor NADP+ is dominating the overall cost of the chemical raw material followed by the ionic liquid (TEGO IL K5) used as solubiliser and the buffer. The overall cost of chemicals was €148/kgproduct. To assess the environmental impact of the process, the E-factor (kgwaste/kgproduct) 132 and the process mass intensity 133 (PMI, kgsubstrate/kgproduct) were calculated. A process model based on initial rate experiments was elaborated and used to improve the process under cost and environmental aspects. Applying several measures...
Databáze:	OpenAIRE
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