An increase of sigma1 receptors in the aged monkey brain
| Autor: | Kazunori Kawamura, Norihiro Harada, Hiroyuki Ohba, Yuichi Kimura, Kiichi Ishiwata, Hideo Tsukada, Tadayuki Kobayashi, Takeharu Kakiuchi, Kiyoshi Matsuno, Shingo Nishiyama, Kenji Ishii |
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| Rok vydání: | 2003 |
| Předmět: |
Senescence
Aging medicine.medical_specialty Sigma-1 receptor General Neuroscience Sigma receptor Central nervous system Binding potential Biology medicine.anatomical_structure Endocrinology In vivo Internal medicine medicine Neurology (clinical) Geriatrics and Gerontology Binding site Receptor Developmental Biology |
| Zdroj: | Neurobiology of Aging. 24:745-752 |
| ISSN: | 0197-4580 |
| Popis: | We evaluated in vivo the effect of aging on the sigma 1 receptors in the monkey brain by the quantitative analysis of the binding of [ 11 C ]SA4503 to sigma 1 receptors with positron emission tomography. Based on a three-compartment model, the influx rate constant K 1 of [ 11 C ]SA4503 from plasma to brain across the blood–brain barrier in all 10 regions investigated became smaller in the aged monkeys (20–28 years old, n =5) than in the young adult monkeys (4–8 years old, n =5), but the reduction was not significant due to the individual differences. On the other hand, the binding potential, which was calculated as the ratio of the association rate constant k 3 to the dissociation rate constant k 4 for the binding of [ 11 C ]SA4503 to sigma 1 receptors in the brain, significantly increased in nine of the brain regions of the aged monkeys to the 160–210% levels of the young monkeys. We concluded that the sigma 1 receptor binding sites increased in the aging process of the monkey brain. |
| Databáze: | OpenAIRE |
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