Magnetic Resonance Imaging of the Bone Marrow following Treatment with Recombinant Human Erythropoietin in Patients with End-Stage Renal Disease
| Autor: | Birgitte Nielsen, Hans Karle, Karl Erik Jensen, Ole Henriksen, Peter Grundtvig Sørensen, Carsten Thomsen, Mikael Jensen, D Stenver |
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| Rok vydání: | 1990 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Bioengineering 030218 nuclear medicine & medical imaging End stage renal disease Biomaterials 03 medical and health sciences 0302 clinical medicine medicine medicine.diagnostic_test business.industry Spin–lattice relaxation Magnetic resonance imaging General Medicine Haematopoiesis medicine.anatomical_structure Erythropoietin 030220 oncology & carcinogenesis Hemodialysis Hemoglobin Bone marrow business medicine.drug |
| Zdroj: | The International Journal of Artificial Organs. 13:477-481 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139889001300806 |
| Popis: | We used magnetic resonance imaging (MRI) to study vertebral bone marrow in hemodialysis patients during treatment with recombinant human erythropoietin (rHuEPO). We found changes in T1 relaxation times and image contrast within 14 days after starting treatment, before any response was seen in the hemoglobin concentration in peripheral blood. The increase in T1 relaxation times, together with earlier reported changes observed with localized magnetic resonance spectroscopy, indicate an alteration in cellular composition of the hemopoietic bone marrow with an increase in the amount of hemopoietic active tissue. MRI may be a useful, non-invasive way of evaluating bone marrow response to different modes of rHuEPO administration and dosage. |
| Databáze: | OpenAIRE |
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