Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats
| Autor: | Natalya B. Demina, Veronika V. Golovach, Galina Sukoyan, Edisher E. Tsivtsivadze, T. Kezeli |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology medicine.medical_treatment Cynara scolymus Cynara Pharmacology biology.organism_classification Skin Aging 03 medical and health sciences Hydroxyproline chemistry.chemical_compound 030104 developmental biology chemistry Chlorogenic acid Pepsin biology.protein medicine Intradermal injection Saline |
| Zdroj: | Pharmacology & Pharmacy. :428-439 |
| ISSN: | 2157-9431 2157-9423 |
| DOI: | 10.4236/pp.2018.910032 |
| Popis: | The aim of the study was to evaluate the efficacy of 2% Cynara scolymus L. extracts in reverse disturbances of collagen metabolism and inflammation in D-galactose induced skin aging model in rats. D-galactose induced aging reproduced in 48 animals of main group, and 12 rats in control group. All animals in main group were randomized for 4 groups: I. aging + saline, II - IV. different manufacturers 2% artichoke extracts (with content of chlorogenic acid < 2.5%) in a dose of intradermal injection 0.13 mg twice at weeks during 4 weeks. Influence of artichoke extracts restored skin relative weight and led to an increase of solubility in neutral salt and acid, and decreased pepsin solubility collagen fraction, restored the hexosamine/collagen (hydroxyproline) ratio and decreased the activity of nuclear transcription factor (NF-kB). Local prolonged treatment with artichoke extracts improved collagen metabolism and attenuated the progression of inflammation in D-galactose induced skin aging model. |
| Databáze: | OpenAIRE |
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