Hormonal status and NIDDM in the European and Melanesian populations of New Caledonia: a case-control study
| Autor: | S Bonnot-Lours, S Barny, R. Defay, E Cacès, Laure Papoz, Dominique Simon |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Nutrition and Dietetics biology business.industry Endocrinology Diabetes and Metabolism Population Case-control study Medicine (miscellaneous) Testosterone (patch) Ethnic origin medicine.disease Sex hormone-binding globulin Endocrinology Diabetes mellitus Internal medicine biology.protein Medicine Melanesians business education Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | International Journal of Obesity. 22:927-934 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0800697 |
| Popis: | OBJECTIVE: To assess ethnic differences in androgenic status related to non insulin-dependent diabetes mellitus (NIDDM) in male and female Melanesians and Europeans of New Caledonia. DESIGN: This is a case-control study nested in a prevalence study for diabetes mellitus in the multiracial population of New Caledonia. SUBJECTS: 186 male subjects were included in the survey (77 Melanesians and 16 Europeans in each case and control group). Each case and control group included 104 female Melanesian subjects (69 premenopausal and 35 post-menopausal). METHODS: Diabetic subjects were matched for age, gender, ethnic group and location, with healthy normoglycaemic subjects. Testosterone levels in men and sex hormone-binding globulin (SHBG) levels in women (measured by radioimmunoassay, RIA) were compared between NIDDM and control subjects in relation to obesity, central adiposity and insulin levels. RESULTS: In both ethnic groups, NIDDM was associated with lower testosterone levels but there was a marked difference among Europeans. Testosterone was negatively associated with the body mass index (BMI) (r=−0.35, P |
| Databáze: | OpenAIRE |
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