Densitometric analysis of eccentric vascular stenoses: Comparison of CO2 and iodinated contrast media
| Autor: | Maria Siebes, Kevin S. Berbaum, William H. Barnhart, Elvira V. Lang, Eric A. Hoffman, Catherine A. Kusnick, Carl M. Black |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Pulsatile flow Digital subtraction angiography medicine.disease Imaging phantom Iodinated contrast media Stenosis Iodinated contrast medicine Eccentric Radiology Nuclear Medicine and imaging Radiology Nuclear medicine business Densitometry |
| Zdroj: | Academic Radiology. 3:985-993 |
| ISSN: | 1076-6332 |
| Popis: | Rationale and Objectives. The authors compared the accuracies of CO 2 and iodinated contrast material in the densitometric quantification of eccentric vascular stenoses. Methods. Five precision-machined eccentric phantom stenoses of 50%, 60%, 70%, 80%, and 90% cross-sectional area narrowing were integrated into a pulsatile ex vivo flow model, imaged with digital subtraction angiography (DSA), and analyzed with densitometry. Relationships between the actual and measured (densitometric) degree of cross-sectional area narrowing were evaluated by using linear regression analysis and paired Student t tests. Comparison measurements were obtained in en face and profile projections. In addition, the effect of iodinated contrast material concentration was evaluated over a range of dilutions (47–282 mg iodine per milliliter). Results. CO 2 yielded significantly more accurate results than did iodinated contrast material (282 mg iodine per milliliter) in the 50%, 60%, and 70% stenosis models when imaging was performed en face ( P 2 DSA when imaging in profile (slope = 0.91, intercept = 2.42% actual stenosis, r = .99). The accuracy of densitometric stenosis estimation was inversely related to the concentration of iodinated contrast material. Conclusion. CO 2 DSA densitometry, under the conditions of these experiments, yields quantitative measures of relative cross-sectional area narrowing that are comparable with, and under some circumstances surpass, those obtained with iodinated contrast material-based DSA. In this model, CO 2 was more useful than iodinated contrast material in 50%–70% stenosis when imaging in the least-optimal plane of stenosis quantification, the en face projection. |
| Databáze: | OpenAIRE |
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