Cytotoxic metabolites from the leaves of the mangrove Rhizophora apiculata

Autor:	Nguyen Phuong Thao, Kieu Thi Phuong Linh, Nguyen Huu Quan, Vu Thanh Trung, Pham Thanh Binh, Nguyen The Cuong, Nguyen Hoai Nam, Nguyen Van Thanh
Rok vydání:	2022
Předmět:	biology Absolute configuration Plant Science biology.organism_classification Biochemistry Rhizophora apiculata chemistry.chemical_compound chemistry Ic50 values Cytotoxic T cell Methanol Mangrove Cytotoxicity Agronomy and Crop Science MCF7 Cells Biotechnology Nuclear chemistry
Zdroj:	Phytochemistry Letters. 47:51-55
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2021.10.014
Popis:	One new 8,4’-oxyneolignan (1) and one new 7,8-dihydrobenzofuranone (2), together with twenty-one known compounds (3‒23) were isolated from the methanol extract of Rhizophora apiculata leaves. The structures of new compounds, as well as their absolute configuration, were determined by a combination of spectroscopic methods and quantum chemical calculations of NMR and ECD data. All isolated compounds were evaluated for their cytotoxicity, and only 2,6-dimethoxy-1,4-benzoquinone (8) exhibited inhibitory effects against SK-LU-1, HepG2, and MCF7 cells with IC50 values in the range of 8.33–14.82 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::154374bd2ac710801d96f38a49809280 https://doi.org/10.1016/j.phytol.2021.10.014 Zobrazit plný text záznamu Full Text from ScienceDirect