Resting Whole Body Energy Metabolism in Class 3 Obesity; from Preserved Insulin Sensitivity to Overt Type 2 Diabetes
| Autor: | Giuseppina Manzoni, Giovanna Castoldi, Emanuele Muraca, Guido Lattuada, Gianluca Perseghin, Stefano Ciardullo, Mattia Pizzi, Pietro Pizzi, Silvia Perra, Alice Oltolini |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Harris–Benedict equation 030209 endocrinology & metabolism Context (language use) Type 2 diabetes 030204 cardiovascular system & hematology medicine.disease Obesity Gastroenterology Respiratory quotient 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Internal Medicine medicine Resting energy expenditure business |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:489-497 |
| ISSN: | 1178-7007 |
| Popis: | Context Insulin resistance and diabetes may influence separately or in combination whole body energy metabolism. Objective To assess the impact of insulin resistance and/or overt type 2 diabetes on resting energy expenditure (REE) in class 3 obese individuals. Design and Setting Retrospective, cross-sectional analysis of a set of data about individuals attending the outpatients service of a single center of bariatric surgery between January 2015 and December 2017. Patients We screened 382 patients in which abnormal thyroid function was excluded, and segregated them in three groups of subjects: patients with type 2 diabetes (T2DM; n=70), non-diabetic insulin-resistant patients with HOMA-IR ≥ 3 (n=236), non-diabetic insulin-sensitive patients with HOMA-IR < 3 (n=75). Main Outcome Measure Resting energy expenditure (REE), body composition and insulin resistance assessed using indirect calorimetry, bioimpedance and HOMA-IR. Results Non-diabetic insulin-sensitive patients resulted to be younger, with lower BMI and higher prevalence of female subjects; meanwhile, non-diabetic but insulin-resistant patients and T2DM patients were not different in terms of anthropometric parameters. REE was higher in T2DM than in non-diabetic insulin-resistant and insulin-sensitive individuals when expressed as percent of the predicted REE (based on Harris Benedict equation) (p |
| Databáze: | OpenAIRE |
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