Tocolytic effect of magnesium sulfate and/or urinary trypsin inhibitor against lipopolysaccharide-induced preterm delivery in mice
| Autor: | Yoshihiro Futamura, Satoshi Kajikawa, Yasunori Shibutani, Nobuhiko Kaga |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Tocolytic agent biology Magnesium Ratón business.industry medicine.medical_treatment Obstetrics and Gynecology chemistry.chemical_element General Medicine Dose–response relationship Endocrinology chemistry Enzyme inhibitor Tocolytic Internal medicine medicine biology.protein Gestation business Saline |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 77:598-602 |
| ISSN: | 0001-6349 |
| DOI: | 10.1034/j.1600-0412.1998.770604.x |
| Popis: | Background. The purpose of this investigation was to evaluate the effect of magnesium sulfate (magnesium) alone or along with urinary trypsin inhibitor (UTI) in a mouse model in the prevention of preterm delivery.Methods. On day 17 of pregnancy, female C3H/HeN mice impregnated by male B6D2F! mice were given two intraperitoneal injections of lipopolysaccharide (LPS; 50 μg/kg) at a 3-hour interval, which treatment induced a 100% incidence of preterm delivery within 25 hours of the second dose. Magnesium (4, 5, 6, 7, or 8 mg/hr, sc), UTI (25 × 104 units/kg, ip), magnesium (5 mg/hr, sc) plus UTI (25 × 104 units/kg, ip), saline solution (0.3 ml/hr, sc), or saline solution (0.1 ml/hr, sc and 2.5 ml/kg, ip) was administered to pregnant animals on day 18 of gestation. UTI was intraperitoneally given 5 times at 2-hour intervals from 8:00 am to 4:00 pm, and magnesium was infused subcutaneously and constantly from 8:00 am to 6:00 pm. In addition, the preventive effect of magnesium on LPS-induced contraction of uteri... |
| Databáze: | OpenAIRE |
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