Fabrication of gold micro-spine structures for improvement of cell/device adhesion
| Autor: | Andreas Offenhäusser, Boris Hofmann, Simon Thiery, G. Panaitov |
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| Rok vydání: | 2011 |
| Předmět: |
Materials science
Fabrication business.industry Nanotechnology Adhesion Condensed Matter Physics Focused ion beam Atomic and Molecular Physics and Optics Surfaces Coatings and Films Electronic Optical and Magnetic Materials Transmission electron microscopy parasitic diseases Surface modification Optoelectronics Electrical and Electronic Engineering business Cell adhesion Electroplating Lithography |
| Zdroj: | Microelectronic Engineering. 88:1840-1844 |
| ISSN: | 0167-9317 |
| DOI: | 10.1016/j.mee.2010.12.074 |
| Popis: | Improvement of the interface contact between biological objects and electronic devices can significantly enhance the quality of electronic signal transfer. The surface of biosensor can be artificially modified in order to strengthen the adhesion of biological cells. We report on results of fabrication of micron and submicron golden spines by means of e-beam lithography and electroplating. The fabrication technique allows easy modification of the size and shape of golden spines by variation of processing parameters. The structures with different spine profiles and spacing have been fabricated for optimization of cell growth conditions. We present the results of growth of rat cortical neurons on the surface of spine modified samples. Well-defined cell guidance was established at the spine arrays. Furthermore, the results of transmission electron microscope and focused ion beam technique confirm the good adhesion between the spines and cell structures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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