Cell death in pandemic and seasonal influenza viruses (VIR2P.1027)
| Autor: | Boris Hartmann, Randy Albrecht, Nada Marjanovic, Soanli Patil, Miguel Fribourg, Stuart Sealfon |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 192:75.16-75.16 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Pandemic influenza virus strains are exceptionally transmissible or virulent, leading to their potential for increased morbidity and mortality. Seasonal influenza strains are relatively predictable causing ~ 40,000 deaths, whereas the influenza pandemic of 1918 caused up to 100 million deaths. Little is known about the virus host interactions that contribute to pandemic and seasonal infections. To gain insight into these differences, we compared temporal gene programs and cell viability in human monocyte-derived dendritic cells (DCs) infected with pandemic (Cal/09, Brevig/1918) or seasonal (Tex/91, NC/99) strains. Influenza infection is associated with cell death at late timepoints related to virion release. Strikingly, as early as 4 hrs after infection, the seasonal strains caused a degree of widespread mRNA degradation and cell death not seen with the pandemic viruses. In contrast, in epithelial cells, only the late occurance (24 hrs) of cell death was observed. These studies identify a dramatic difference in the virus-host interaction between seasonal and pandemic influenza viruses in a crucial cell type of the innate and adaptive immune system. |
| Databáze: | OpenAIRE |
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