Effects of Oxygen Therapy on Left Ventricular Function in Patients with Cheyne- Stokes Respiration and Congestive Heart Failure
| Autor: | Samuel L. Krachman, Thomas Nugent, Joseph Crocetti, Gilbert E. D&rsquo, null Alonzo, Wissam Chatila |
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| Rok vydání: | 2005 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Ejection fraction business.industry medicine.medical_treatment Radionuclide ventriculography medicine.disease Cheyne–Stokes respiration respiratory tract diseases Neurology Internal medicine Heart failure Oxygen therapy Respiration medicine Cardiology cardiovascular diseases Neurology (clinical) Continuous positive airway pressure medicine.symptom business Oxygen saturation (medicine) |
| Zdroj: | Journal of Clinical Sleep Medicine. :271-276 |
| ISSN: | 1550-9397 1550-9389 |
| Popis: | STUDY OBJECTIVES Whereas both oxygen therapy and nasal continuous positive airway pressure (CPAP) decrease the apnea-hypopnea index (AHI) in patients with Cheyne-Stokes respiration (CSR) and congestive heart failure (CHF), only nasal CPAP is known to affect the left ventricular ejection fraction (LVEF). We therefore evaluated the effects of 1 month of nocturnal oxygen therapy on LVEF. METHODS Ten patients (52 +/- 12 years) with CHF (LVEF of 12% +/- 5%) and CSR (AHI 57 +/- 61 events/hour) were studied. Polysomnograms identified CSR and were repeated on oxygen initially (oxygen night 1 [2 L/min]) and after 30 nights (oxygen night 2). LVEF was measured by radionuclide ventriculography. RESULTS Oxygen therapy decreased the AHI from a baseline of 57 +/- 61 to 9 +/- 11 and 12 +/- 17 events per hour during oxygen nights 1 and 2, respectively (p < .05), with no difference between treatment nights. The lowest oxygen saturation increased during oxygen nights 1 and 2, from a baseline of 87% +/- 7% to 94% +/- 4% and 91% +/- 7%, respectively (p < .05), with no difference between treatment nights. The LVEF did not significantly change from a baseline of 22% +/- 11% to 19% +/- 9% after 1 month of nocturnal oxygen (p = .05). Compared to baseline, there was no change in circulation time during oxygen nights 1 and 2, from 24 +/- 8 seconds to 30 +/- 15 seconds and 23 +/- 6 seconds, respectively (p = .2). Total sleep time, sleep efficiency, and sleep architecture, when compared with baseline, remained unchanged during both oxygen therapy nights. CONCLUSIONS Although 1 month of nocturnal oxygen therapy decreases the AHI in patients with CSR and CHF, there is no improvement in left ventricular function. |
| Databáze: | OpenAIRE |
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