Correction of dysfunction of enzyme systems of microsomal oxidation, glucuronidation, and glutathione conjugation of xenobiotics in the liver of rats with deoxycholate intoxication

Autor:	M. I. Bushma, I. V. Zverinskii, A. V. Vasil'ev, L. F. Legon'kova
Rok vydání:	2000
Předmět:	Glucuronosyltransferase biology Deoxycholic acid Glucuronidation General Medicine Glutathione Monooxygenase General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound medicine.anatomical_structure chemistry Biochemistry Hepatocyte biology.protein medicine Microsome Xenobiotic
Zdroj:	Bulletin of Experimental Biology and Medicine. 129:253-256
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02433898
Popis:	Intoxication with deoxycholic acid disturbed the integrity of hepatocyte plasma membranes (elevation of alanine transaminase activity in the plasma) and inhibited the monooxygenase, glucuronosyltransferase, and glutathione S-transferase systems in rat liver. Heptral and cordiaminum did not affect the integrity of plasma membranes, while α-tocopherol and, especially, ursofalk produced membrane-protective effects. Ursofalk and, especially, cordiaminum are far superior to α-tocopherol and heptral in their ability to normalize functions of the monooxygenase, glucuronosyltransferase, and glutathione S-transferase systems in rat liver.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1508a69b22a8811fe6694977a78dcff2 https://doi.org/10.1007/bf02433898 Zobrazit plný text záznamu Full text from SpringerLink