Developing Molecular Pharmacology of BK Channels for Therapeutic Benefit
| Autor: | M L Garcia, G J Kaczorowski |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Agonist BK channel biology business.industry Drug discovery medicine.drug_class Dehydrosoyasaponin I Molecular Pharmacology Pharmacology 03 medical and health sciences 030104 developmental biology Smooth muscle Hemorrhagic shock biology.protein Medicine business Neuroscience Ion channel gating |
| DOI: | 10.1016/bs.irn.2016.02.013 |
| Popis: | High conductance, calcium-activated potassium (BK) channels (KCa1.1) are important in regulating physiologic responses in many types of tissues and, as such, present opportunities for development of new therapeutic agents. Both channel agonists and inhibitors could have therapeutic utility, depending on medical application under consideration. However, characterization of molecular pharmacology of BK channels is incomplete and has been difficult to accomplish because of paucity of chemical leads that are acceptable templates for Medicinal Chemistry investigation. Only through continued prosecution of new high-throughput screening campaigns can this situation be rectified. Examples are presented of BK channel agonist and inhibitor discovery paradigms which will be useful for progressing BK channel future drug discovery strategies. |
| Databáze: | OpenAIRE |
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