Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
| Autor: | Safinaz E. El-Toukhy, Rehab Selim Moustafa, Doaa Sayed Mohammed, Asmaa Abd El Wakeel Elsehmawy, Nora Mohammed Ahmed Seliem |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Renal function 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Gastroenterology Nephropathy 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine Medicine Chemerin Pharmacology Type 1 diabetes biology business.industry nutritional and metabolic diseases medicine.disease Apelin biology.protein Albuminuria Microalbuminuria medicine.symptom business |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12:383-389 |
| ISSN: | 1178-7007 |
| Popis: | Background Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be due to micro or macrovascular complications. Diabetic renal disease or nephropathy is a common complication of DM, clinically silent and the only detectable abnormality due to the presence of microalbuminuria. Subjects and methods This study was a case-control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls. Serum apelin (APLN), chemerin, cholesterol, and triglycerides (TG) levels were measured for each case. Also, albumin/creatinine ratio was analyzed in random urine sample. Results Comparison between T1DM patients and controls revealed that serum apelin, chemerin, cholesterol, TG levels, and albuminuria were significantly increased in cases compared to their controls. Significant positive correlations were found between HbA1c% and albuminuria for APLN and chemerin in the diabetic group. Whereas significant negative correlations were found between apelin and glomerular filtration rate (GFR). Conclusion Increased levels of serum apelin and chemerin in T1DM patients may be considered as promising adipokines for the development of diabetic complication. |
| Databáze: | OpenAIRE |
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