Stability testing of tacrolimus-loaded poly(ԑ-caprolactone) nanoparticles by physicochemical assays and Raman spectroscopy
| Autor: | Guilherme dos Anjos Camargo, Carlos Jacinto, Andressa Novatski, Ueslen Rocha Silva, D. T. Dias, Amanda Martinez Lyra, Elizangela Anazilda do Nascimento, Jessica Mendes Nadal, Lucas S. de Lara, Amanda Roderjan Cray da Costa Filha, Paulo Vitor Farago |
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| Rok vydání: | 2020 |
| Předmět: |
Aqueous solution
biology Chemistry Streptomyces tsukubaensis 010401 analytical chemistry Dispersity 02 engineering and technology Permeation 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Drug delivery Zeta potential Particle size 0210 nano-technology Caprolactone Spectroscopy Nuclear chemistry |
| Zdroj: | Vibrational Spectroscopy. 110:103139 |
| ISSN: | 0924-2031 |
| DOI: | 10.1016/j.vibspec.2020.103139 |
| Popis: | Tacrolimus (TAC) or FK506 is a macrolide lactone isolated from the bacterial fermentation of Streptomyces tsukubaensis which belongs to the group of calcineurin inhibitors. Its main mechanism of action is to act on the immune system. In addition, this drug has been widely explored for skin disorders. However, TAC shows high molecular weight, high hydrophobicity, and low water solubility that can limit its ability to effectively permeate through the skin. Hence, it becomes imperative to develop a percutaneous drug delivery system for increasing its permeation in relation to the conventional ointment and for reducing the dose and the adverse effects as erythema, itching, and burning. Therefore, the aim of this work was to investigate the stability of colloidal suspensions of TAC-loaded poly(ԑ-caprolactone) (PCL) nanoparticles that were stored at room temperature for 120 days. In that sense, pH, particle size, polydispersity index (PDI), zeta potential, and Raman spectroscopy were performed. Significant decrease of pH (p 0.05) during the time interval investigated. Zeta potential presented statistically significant difference (p |
| Databáze: | OpenAIRE |
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