| Popis: |
A synthesis is described of the protected linear decapeptide: N-benzyloxycarbonyl-S-benzyl-L-cysteinyl-L-tyrosyl-L-tyrosyl-L-tyrosyl-L-glutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-Ne-p-toluene-sulphonyl-L-lysylglycineamide (VI) in analytically pure form. Removal of the blocking groups from VI, followed by cyclization through oxidation, yielded a preparation which was assumed to contain an analogue of lysine-vasopressin, with L-phenylalanine “replaced” by two consecutive L-tyrosyl radicals. This synthesis was performed in connection with our previous studies on the relation between chemical structure and biological activity in the oxytocin and vasopressin field. |
