The Effect of Combination of Quercetin And Glibenclamide on Myocardial Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Expression In Type 2 Diabetic Rat
| Autor: | Syaefudin Ali Akhmad, Asri Hendrawati, Tasmini, Ahmad Hamim Sadewa |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Metabolic disorder General Medicine medicine.disease Placebo Glibenclamide Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Endocrinology chemistry Internal medicine Diabetic cardiomyopathy Diabetes mellitus Heart failure medicine business Quercetin medicine.drug |
| Zdroj: | Bangladesh Journal of Medical Science. 16:302-306 |
| ISSN: | 2076-0299 2223-4721 |
| DOI: | 10.3329/bjms.v16i2.31943 |
| Popis: | Background. Diabetes mellitus (DM) is a metabolic disorder syndrome that marked by hyperglycemia. The main macrovascular complication is heart failure due to diabetic cardiomyopathy. Hyperglycemia can increase reactive oxygen species (ROS) and lipid peroxidation that induce cellular damage. Quercetin is an antioxidant that reduce hyperglycemia and ROS by modify the expression of nuclear factor erythroid 2-related factor 2 (Nrf 2).Objective. The aim of this research was to investigate the effect of combination of quercetin and glibenclamide on myocardial nuclear factor erythroid 2-related factor 2 (nrf 2) expression in type 2 diabetic rat compared with no combination.Methods. The rats were divided randomly into nine groups (each group consisted of four rats). The control group consist of a normal group that received placebo, DM control groups that received placebo and glibenclamide and intervention groups received quercetin 5, 20 and 80 mg/kgbw/day and combination of quercetin with 5 mg/kgbw/day of glibenclamide orally for a period of four weeks. The expression of myocardial Nrf 2 was measured by immunohistochemistry. Data was analyzed by ANOVA and p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|