Highly enantioselective Michael/cyclization tandem reaction between dimedone and isatylidene malononitriles

Autor:	Feng Sha, Jia-Long Hu, Qiong Li, Xin-Yan Wu
Rok vydání:	2018
Předmět:	010405 organic chemistry Organic Chemistry Enantioselective synthesis 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Cascade reaction chemistry Dimedone Drug Discovery Organic chemistry Bifunctional
Zdroj:	Tetrahedron. 74:7148-7155
ISSN:	0040-4020
DOI:	10.1016/j.tet.2018.10.029
Popis:	A highly enantioselective Michael/cyclization tandem reaction between dimedone and isatylidene malononitriles has been developed. With 5 mol% of bifunctional organocatalyst C15, chiral spiro[2-amino-4H-pyran-oxindole] derivatives were obtained in excellent yields (97–99%) with excellent enantioselectivities (up to > 99% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::14e72274f176101037d85d9075b811c2 https://doi.org/10.1016/j.tet.2018.10.029 Zobrazit plný text záznamu Full Text from ScienceDirect