Acyclic 2-Ethynylnaphthalene-Modified 8-Aza-3,7-dideaza-2′-deoxyadenosine Allows Thymine Discrimination by Probing the DNA Minor Groove Environment

Autor:	Yoshio Saito, Yurino Oku, Misaki Kai, Saika Kobayashi, Ryuzi Katoh
Rok vydání:	2023
Předmět:	Organic Chemistry
Zdroj:	Synlett.
ISSN:	1437-2096 0936-5214
DOI:	10.1055/a-2071-7168
Popis:	Two novel acyclic environment-sensitive fluorescent nucleosides named ac37zA and an37zA are synthesized and their photophysical properties are investigated. Both ac37zA and an37zA exhibit dual fluorescence emission depending upon molecular coplanarity. Oligodeoxynucleotide probes containing ac37zA clearly discriminate perfectly matched thymine in target DNA strands by strong charge transfer (CT) emission in the longer wavelength region and by strong quenching of emission from the twisted conformation in the mismatched case.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::14e4f58edca54e99373645a0ecaaae4f https://doi.org/10.1055/a-2071-7168 Zobrazit plný text záznamu