Abstract 540: Magnesium Improves Cardiac Diastolic Function by Modulating Mitochondria
| Autor: | Euy-Myoung Jeong, Samuel C. Dudley, Go Eun Jeong, An Xie, Anyu Zhou, Man Liu, Eui Yong So, Guangbin Shi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Physiology Magnesium business.industry Saturated fat chemistry.chemical_element Mitochondrion medicine.disease medicine.disease_cause Diabetes type ii Insulin resistance Endocrinology chemistry Diabetes mellitus Internal medicine medicine Diastolic function Cardiology and Cardiovascular Medicine business Oxidative stress |
| Zdroj: | Circulation Research. 123 |
| ISSN: | 1524-4571 0009-7330 |
| Popis: | Rationale: A diet rich in saturated fat has been found to induce diabetes mellitus (DM) accompanied by myocardial mitochondrial dysfunction, insulin resistance, and magnesium (Mg) deficiency. The most prominent characteristic of diabetic cardiomyopathy is cardiac diastolic dysfunction (DD). Mg supplementation improves the heart rate variability and arterial elasticity in chronic heart failure. Recently, we have reported that mitochondrial reactive oxygen species (mitoROS) play a critical role in the progress of DD and diastolic heart failure. Therefore, we hypothesized that Mg supplementation would benefit diastolic function by improving mitochondrial function. Methods and Results: High fat diet (HFD)-induced diabetic mouse hearts showed cardiac DD with increased E/e’ (45±2 in DM mice vs. 32±2 in control mice), increased left ventricular diastolic volume (LVDV, 80±1 μL in DM vs. 61±4 μL in control), and increased incidence of DD (9 of 10 mice in DM vs 1 of 10 mice in control; P2+ overload (3.7±1.3-fold; P2+ overload in DM mice. Conclusion: These results indicate that Mg supplementation improved mitochondrial function, reduced oxidative stress, and prevented diastolic dysfunction in DM. |
| Databáze: | OpenAIRE |
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