Steroid Hormones and Tourette??s Syndrome
| Autor: | James F. Leckman, Robert A. King, Lawrence Scahill, Frederick Naftolin, Maureen T. Hardin, David L. Keefe, Nancy J. Charest, Donald J. Cohen, Bradley S. Peterson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Chemotherapy
Pediatrics medicine.medical_specialty business.industry medicine.drug_class medicine.medical_treatment Antiandrogen Crossover study law.invention Flutamide Surgery Androgen receptor Psychiatry and Mental health chemistry.chemical_compound Randomized controlled trial chemistry law medicine Pharmacology (medical) Antiandrogen Therapy business Hormone |
| Zdroj: | Journal of Clinical Psychopharmacology. 14:131 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/00004714-199404000-00008 |
| Popis: | We report here the first use in Tourette's syndrome of the nonsteroidal androgen receptor blocking agent flutamide. One man and one woman underwent open trials of the medication, and a second man participated in a placebo-controlled, double-blind crossover trial. Improvement in tic symptoms ranged from 45 to 60%. The improvement was sustained in the woman during daily flutamide use and in one man during its intermittent use. One man's symptoms became refractory to treatment after 5 weeks of flutamide use, whereas the woman became depressed and had protracted diarrhea during her treatment. |
| Databáze: | OpenAIRE |
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