Current Evaluation of Lymphoedema and Assessment by Lymphoscintigraphy of the Effect of a Micronized Flavonoid Fraction (Daflon 500 mg) in the Treatment of Upper Limb Lymphoedema

Autor:	P. Rambert, A. P. Pecking
Rok vydání:	1994
Předmět:	medicine.medical_specialty business.industry General Medicine 030204 cardiovascular system & hematology 030230 surgery Daflon 500 Surgery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Upper limb Cardiology and Cardiovascular Medicine business
Zdroj:	Phlebology: The Journal of Venous Disease. 9:26-29
ISSN:	1758-1125 0268-3555
DOI:	10.1177/0268355594009001s09
Popis:	Objective: To assess the effect of Daflon 500 mg on upper lymphoedema occurring after conventional treatment of breast cancer. Design: Open, pilot, single centre trial. Setting: Hospital outpatients attending a University Hospital. Patients: Ten female patients (aged 44–64 years) whose previous treatment for breast cancer was followed by upper limb lymphoedema (mean (SD) time delay = 17±7 months). Interventions: Oral administration of a daily dose of two tablets of Daflon 500 mg for 6 months. Main outcome measures: Symptoms, affected upper limb volume and parameters of radionuclide lymphoscintigraphy using technetium-99m. Results: All patients experienced improvement of symptoms and limb volume (mean volume decrease of the swollen limb: 6.80%). Functional parameters assessed with scintigraphy were significantly improved (half-life: 147.4 (14.9) to 144.1 (14.9) min, p < 0.01; clearance of the colloid: 25.9 (2.5) to 28.3 (2.8) Conclusion: These preliminary results suggest that this therapy is effective for the treatment of lymphoedema.
Databáze:	OpenAIRE
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