271Coronary microvascular dysfunction during long term metabolic derangement in swine
| Autor: | I.M. Heinonen, Dirk J. Duncker, Ahj Danser, V J De Beer, Daphne Merkus, Oana Sorop, N.S. Van Ditzhuijzen, S.J. Koopmans, M. Van Den Heuvel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry Cholesterol Snap Bradykinin Vasodilation medicine.disease Constriction Coronary artery disease chemistry.chemical_compound Endocrinology chemistry Physiology (medical) Diabetes mellitus Internal medicine Medicine medicine.symptom Cardiology and Cardiovascular Medicine business Vasoconstriction |
| Zdroj: | Cardiovascular Research. 103:S49.1-S49 |
| ISSN: | 1755-3245 0008-6363 |
| DOI: | 10.1093/cvr/cvu084.1 |
| Popis: | Dysfunction of the coronary microvasculature has been proposed as one of the important contributors to the diabetes mellitus (DM) associated coronary artery disease (CAD). How different aspects of such dysfunction manifest during disease progression remains incompletely understood. Therefore we studied the time course of coronary microvascular dysfunction in a large animal model of metabolic derangement. Swine with streptozotocin-induced DM type II were fed a high fat diet for up to 15 mo. Coronary small arteries (300 μm) were studied in vitro at 2mo (n=6), 6mo (n=7) and 15 mo (n=5) follow up and compared to healthy controls (n=12, Control). All diabetic groups showed marked hyperglycemia (16±3, 18±4 and 18±1 mmol/l at 2mo, 6mo and 15mo resp.) and hypercholesterolemia (14±2, 17±2 and 18±3 mmol/l) as compared to Control (glucose: 5±1 and cholesterol: 2.0±0.3 mmol/l; all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|