Detecting impaired glucose tolerance or type 2 diabetes mellitus by means of an oral glucose tolerance test in HIV-infected patients

Autor: PierMarco Piatti, Alba Bigoloni, Silvia Nozza, F Visco, Nicola Gianotti, Stefania Salpietro, Concetta Vinci, Laura Galli, Beatrice Barda, A Castagna, Giulia Gallotta, Adriano Lazzarin
Rok vydání: 2010
Předmět:
Zdroj: HIV Medicine. 12:109-117
ISSN: 1464-2662
DOI: 10.1111/j.1468-1293.2010.00860.x
Popis: Objective As a proactive diagnosis of diabetes mellitus (DM) may prevent the onset of severe complications, we used an oral glucose tolerance test (OGTT) to check for impaired glucose tolerance (IGT) and DM in patients with long-standing HIV infection and long durations of exposure to antiretroviral drugs with normal fasting plasma glucose (FPG) levels. Methods This was a cross-sectional, single-centre study. The homeostatic model assessment for insulin resistance (HOMA-IR) and 2-h post-load glucose levels were used to evaluate patients with known HIV-1 infection since before 1988 and no previous diagnosis of DM for whom data on hepatitis C virus (HCV) and hepatitis B virus (HBV) infection were available. Results Eighty-four Caucasian patients [67 (80%) male; median age 45.7 years; range 43.8–49.1 years] were able to be evaluated; 65 (77%) were coinfected with HCV, and seven (8%) were coinfected with HBV. Median (interquartile range [IQR]) exposure to antiretrovirals was 12.8 (10.4–16.5) years. Fifteen patients (18%) had a previous AIDS-defining event, 64 (76%) had HIV RNA
Databáze: OpenAIRE
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