Synthesis of Calix[4]arene Triflates and Their Unusual Chemical Reactivity in Palladium-Catalyzed Reactions

Autor:	John N. Bridson, Sultan Chowdhury, Paris E. Georghiou
Rok vydání:	2000
Předmět:	Tris chemistry.chemical_compound chemistry Organic Chemistry Clathrate hydrate Benzophenone Crystal structure Phenylboronic acid Triethylamine Medicinal chemistry Deoxygenation Derivative (chemistry)
Zdroj:	The Journal of Organic Chemistry. 65:3299-3302
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo000003u
Popis:	The formation of p-tert-butylcalix[4]arene mono-, bis-, tris-, and tetrakistriflates 3, 2, 4, and 5, respectively, and their respective reactions, under typical Pd-catalyzed carbonylative, Suzuki-Miyaura coupling, or deoxygenation conditions are described. A novel, nonsolvent-derived 1:1 clathrate (6) of benzophenone and 3 was formed from the palladium-catalyzed carbonylative reaction of phenylboronic acid and 2. The X-ray crystal structure of this first nonsolvent-derived clathrate of a calix[4]arene derivative is reported. Another 1:1 clathrate of triethylamine and 3 was formed during the attempted Pd-catalyzed deoxygenation of 2.
Databáze:	OpenAIRE
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