Sedative Effect of Walnut Leaf Extract and Juglone, an Isolated Constituent
| Autor: | J. Fialip, A.-M. Privat, Andrée Carnat, M. Gîrzu, A. Carnat, Jean-Louis Lamaison |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
Chloroform biology Traditional medicine medicine.drug_class Sedation Pharmaceutical Science Juglandaceae General Medicine Pharmacognosy biology.organism_classification chemistry.chemical_compound Complementary and alternative medicine chemistry Sedative Drug Discovery medicine Molecular Medicine medicine.symptom Diazepam Juglone Juglans medicine.drug |
| Zdroj: | Pharmaceutical Biology. 36:280-286 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1076/phbi.36.4.280.4580 |
| Popis: | Sedative activity of Juglans regia L. (Juglandaceae) chloroform extract and of one of its isolated constituents was evaluated in mice. Dry chloroform extract and juglone, orally administered at 6.5 mg/kg and 0.125 mg/kg, respectively, induced marked sedation as measured by two tests (actimeter and sleep potentiation), compared with controls (diazepam, 2 mg/kg, per os). A separation method of juglone from chloroform extract was developed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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