| Autor: |
F. E. Cole, O. Coker, B. Carriere, Dirk J. Kok, J. Vaughn, A. Annaloro, D. T. Erwin, J. Alam |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Urolithiasis 2 ISBN: 9781461360919 |
| DOI: |
10.1007/978-1-4615-2556-1_104 |
| Popis: |
The search for reliable, rapid and accurate tools to enable the clinician to predict stone recurrences and prevent patients from forming subsequent calculi has been marginally successful. Chemical measurements of urine constituents dictating the thermodynamics of calcium oxalate monohydrate (COM) stone formation have proved to be of limited use in treating this disease, since crystalluria is as frequent in normal urines as in urines from stone formers1. More recently, therefore, attention has turned to methods for evaluating physicochemical processes which dictate rapid growth and agglomeration of COM particle size2, because the transit time of stones in the urinary tract is so short and the agglomeration process is so rapid3. The effect of urine on crystal agglomeration may therefore be a more sensitive index of the likelihood that a patient will form and retain stones4. In the present studies we examined the effects of Tamm-Horsfall protein, a urinary glycoprotein which is a variable constituent in renal stones5. We quantitatively 6 removed THP from the urines of stone formers by ultrafiltration and assessed its structure, immunologic reactivity and its effects on COM solubility, growth and agglomeration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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