Dynamic impact of inflammation-based indices in colorectal cancer patients receiving FOLFOX-based chemotherapy
| Autor: | Jianming Qiu, Yong Tao, Ningning Jin, Hongshuang Pang, Hongbiao Wu, Danping Yuan, Ningning Wu, Yuepeng Cao, Dongfang Liu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Chemotherapy Prognostic factor medicine.medical_specialty Multivariate analysis Receiver operating characteristic Proportional hazards model business.industry Colorectal cancer medicine.medical_treatment medicine.disease body regions 03 medical and health sciences 030104 developmental biology 0302 clinical medicine FOLFOX 030220 oncology & carcinogenesis Internal medicine medicine Neutrophil to lymphocyte ratio business medicine.drug |
| Zdroj: | Cancer Management and Research. 11:2817-2829 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s191712 |
| Popis: | Background: Inflammatory cellular response is implicated in the pathogenesis of colorectal cancer (CRC). Nevertheless, the dynamic effects of inflammatory index coNLR (neutrophil-to-lymphocyte ratio)-PLR (platelet-to-lymphocyte ratio) during chemotherapy remain elusive. Methods: The baseline clinical data and laboratory parameters of 480 CRC patients who received palliative resection of primary tumors and FOLFOX-based chemotherapy from January 2007 to January 2013 were retrospectively analyzed. Receiver operating characteristic curves were plotted to obtain the predictive NLR and PLR values, and to calculate the coNLR-PLR score. The Kaplan-Meier method was used to estimate the rates of recurrence-free survival (RFS) and overall survival (OS), and the Cox proportional hazards model was employed for analysis. Results: The dynamic cut-off values of NLR during four periods of chemotherapy were 3.029, 2.466, 2.102 and 1.795, respectively, and those of PLR were 216.438, 187.572, 169.027 and 174.368, respectively. A higher coNLR-PLR was significantly associated with lower rates of RFS and OS (P |
| Databáze: | OpenAIRE |
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