Pharmacokinetics of ascorbic acid in man

Autor:	G. Seidel, G. Zetler, C. P. Siegers, H. Iven
Rok vydání:	1976
Předmět:	Pharmacology Drug Vitamin Chemistry media_common.quotation_subject Capsule General Medicine Ascorbic acid Blood proteins Bioavailability chemistry.chemical_compound Pharmacokinetics Oral administration Pharmacology (medical) media_common
Zdroj:	European Journal of Clinical Pharmacology. 10:273-282
ISSN:	1432-1041 0031-6970
Popis:	The pharmacokinetic characteristics of ascorbic acid have been investigated in normal adult volunteers, using a two-compartment open model. After oral administration in a normal gelatine capsule the bioavailability of ascorbic acid was 69%. It was 98% when a sustained-release preparation was given in an identical capsule. During daily oral intake of ascorbic acid 1 g in the sustained-release form blood levels reached the equilibrium state within 3 days. Daily doses of ascorbic acid 1 g resulted in tissue saturation in 7 days, with a profound change in the pharmacokinetics of the vitamin. The binding of ascorbic acid to plasma proteins was low (≃24%). Its significance for the pharmacokinetic behaviour of the drug is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::14ac09cd7155f55c441113dbef7f69cd https://doi.org/10.1007/bf00558340 Zobrazit plný text záznamu Full text from SpringerLink