Pharmacokinetics of ascorbic acid in man
Autor: | G. Seidel, G. Zetler, C. P. Siegers, H. Iven |
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Rok vydání: | 1976 |
Předmět: | |
Zdroj: | European Journal of Clinical Pharmacology. 10:273-282 |
ISSN: | 1432-1041 0031-6970 |
Popis: | The pharmacokinetic characteristics of ascorbic acid have been investigated in normal adult volunteers, using a two-compartment open model. After oral administration in a normal gelatine capsule the bioavailability of ascorbic acid was 69%. It was 98% when a sustained-release preparation was given in an identical capsule. During daily oral intake of ascorbic acid 1 g in the sustained-release form blood levels reached the equilibrium state within 3 days. Daily doses of ascorbic acid 1 g resulted in tissue saturation in 7 days, with a profound change in the pharmacokinetics of the vitamin. The binding of ascorbic acid to plasma proteins was low (≃24%). Its significance for the pharmacokinetic behaviour of the drug is discussed. |
Databáze: | OpenAIRE |
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