Survival, Proliferation and Cell Cycle of Swine Fibroblast after Infection with Salmonella enterica
| Autor: | Tomokazu Fukuda, Kengo Kuroda, Yijie Guo, Hiroshi Yoneyama, Junko Nishimura, Bernard M. Hang’ombe, Xu Jun, Mizuki Masuda, Katsuya Okuno, Emiko Isogai |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Salmonella Programmed cell death biology Cell Salmonella infection General Medicine Cell cycle biology.organism_classification medicine.disease_cause medicine.disease Microbiology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Apoptosis Salmonella enterica medicine Fibroblast |
| Zdroj: | Advances in Microbiology. :942-952 |
| ISSN: | 2165-3410 2165-3402 |
| Popis: | Food-borne salmonellosis continues to be a major health concern worldwide. Carry-contamination of Salmonella frequently occurs in meat production. We focused on cell dynamics of swine fibroblasts after infection with Salmonella enterica serovar Enteritidis and Typhimurium, because fibroblast can be a target cell for Salmonella latent infection. It was found that both S. Enteritidis and S. Typhimurium were able to adhere and invade to swine fibroblasts. The proliferations in fibroblasts were different between each serovar. S. Enteritidis reached to the maximum at 24 hr after infection while S. Typhimurium did not. In addition, the decrease in the G0/G1 phase cells and increase in G2/M phase cells on the fibroblast were observed by both Salmonella infection. Cell death including apoptosis in the cells was inhibited by the infection of Salmonella. These results suggest that nontyphoidal Salmonella can survive for the long term by modifying bacterial cell proliferation and preventing cell death of host cells. |
| Databáze: | OpenAIRE |
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