| Autor: |
L. Langerman, Gilbert J. Grant, Mark I. Zakowski, Kristien Vermeulen |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Acta Anaesthesiologica Scandinavica. 45:906-910 |
| ISSN: |
0001-5172 |
| Popis: |
Background: The research on conductive analgesia induced by perineural opioids generated a large body of conflicting data. In this study we reassessed the antinociceptive response to perineural administration of morphine, fentanyl or meperidine in a rat model. Methods: Analgesia was assessed using the hind paw withdrawal latency (HPWL) response to radiant heat. The opioid dose producing 20% of maximal possible effect (20%MPE) for systemic analgesia was calculated for each drug. Then sciatic blockade was performed with the dose corresponding to 20%MPE. The injected hind paw was used to measure direct perineural effect and the contralateral hind paw was used as an indicator of systemic effect. Results: The response latency produced by morphine or fentanyl was not significantly different for ipsilateral (perineural effect) or contralateral (systemic effect) paw (27±11 vs 28±16 and 3l±16 vs 23±16 s, respectively). However, the meperidine group showed significantly higher %MPE for the ipsilateral paw (79±32 s) than for the contralateral paw (27±22 s). Conclusions: The results indicate that perineural fentanyl or morphine do not produce analgesia. Perineural block produced by meperidine was attributed to local anesthetic-like effect, rather than to drug interaction with opioid receptor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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