Unraveling the mysteries of MYT1L: From reprogramming factor to multifaceted regulator of neuronal differentiation

Autor:	Aniket Bhattacharya, M. Chiara Manzini
Rok vydání:	2021
Předmět:	General Neuroscience Neuronal differentiation Regulator Biology medicine.disease medicine.anatomical_structure nervous system medicine Transcriptional regulation Autism Neuron Haploinsufficiency Neuroscience Reprogramming De novo mutations
Zdroj:	Neuron. 109:3713-3715
ISSN:	0896-6273
DOI:	10.1016/j.neuron.2021.11.006
Popis:	In this issue of Neuron, Chen et al. (2021) generated a mouse model for haploinsufficiency of MYT1L. MYT1L is widely used in neuronal reprogramming, and de novo mutations have been linked to a neurodevelopmental syndrome. Extensive characterization in this study better delineates MYT1L's role in transcriptional regulation and neuronal differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1498e73cd7dbe23228a0753162b94abe https://doi.org/10.1016/j.neuron.2021.11.006 Zobrazit plný text záznamu